Search results for " Alzheimer Disease"

showing 10 items of 38 documents

An intraoral drug delivery device for long term therapies: application in Alzheimer’s disease

2009

IntelliDrug intraoral device Alzheimer diseaseSettore CHIM/09 - Farmaceutico Tecnologico Applicativo
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Amyloid precursor protein in platelets of patients with Alzheimer disease: effect of acetylcholinesterase inhibitor treatment.

2001

BACKGROUND:Amyloid precursor protein (APP) forms with apparent molecular weights of 130, 110, and 106 kd are present in human platelets. It has been demonstrated that Alzheimer disease (AD) is specifically associated with a decreased APP forms ratio in platelets. OBJECTIVE:To investigate whether acetylcholinesterase (AChE) inhibitor treatment modifies the ratio of platelet APP forms in patients with AD. PATIENTS AND METHODS:From a large sample of patients with probable AD, 30 with mild to moderate AD were selected. Each patient underwent a clinical evaluation including the Mini-Mental State Examination (MMSE) and platelet APP forms analysis at baseline and after 30 days. During this interva…

Blood PlateletsMalemedicine.medical_specialtyIsoformmedicine.drug_classBlotting WesternAlzheimer disease; biomarker; platelet; Amyloid Precursor Protein; Isoformchemistry.chemical_compoundAmyloid beta-Protein PrecursorArts and Humanities (miscellaneous)PiperidinesDonepezil HydrochlorideInternal medicinemental disordersAmyloid precursor proteinMedicineHumansPlateletDonepezilLongitudinal StudiesDonepezilCholinesteraseAgedamyloid alzheimer diseaseplateletbiologybusiness.industryMiddle AgedAcetylcholinesteraseEndocrinologychemistryAcetylcholinesterase inhibitorEnzyme inhibitorIndansAmyloid Precursor Proteinbiology.proteinbiomarkerSettore MED/26 - NeurologiaFemaleNeurology (clinical)Cholinesterase InhibitorsAlzheimer diseasebusinessmedicine.drugFollow-Up Studies
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Lexical and conceptual components of stem completion priming in patients with Alzheimer's disease

1999

This study evaluated the hypothesis of dissociation between normal lexical but deficient conceptual repetition priming in patients with Alzheimer's disease (AD). For this purpose, we administered to patients with AD and age-matched normal controls the Stem Completion task. In Experiment 1, the level of word processing during study was manipulated by requiring subjects to count vowels (graphemic condition) or generate meanings (semantic condition) of target words. In Experiment 2, the presentation modality was varied during the study to obtain an intramodal and crossmodal repetition priming. Probably due to a floor effect of performance in the graphemic condition, in Experiment 1, AD patient…

MaleDissociation (neuropsychology)Cognitive NeuroscienceConcept FormationWord processingRepetition primingExperimental and Cognitive PsychologyAssociationBehavioral NeuroscienceMemoryAlzheimer DiseasemedicineHumansMemory disorderIntramodal dispersionAgedAnalysis of VarianceAlzheimer's dementiaCrossmodalMiddle Agedmedicine.diseaseSemanticsRepetition primingAnalysis of Variance; Reading; Association; Humans; Alzheimer Disease; Aged; Mental Recall; Cognition Disorders; Semantics; Concept Formation; Speech Perception; Practice (Psychology); Cues; Case-Control Studies; Middle Aged; Female; MaleReadingPractice PsychologicalPractice (Psychology)Case-Control StudiesMental RecallSpeech PerceptionFemaleSettore MED/26 - NeurologiaImplicit memoryCuesPsychologyCognition DisordersPriming (psychology)Cognitive psychology
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Preclinical phase of Alzheimer's disease: Guideline for recognition and study of patients with mild cognitive impairment

2002

mild cognitive impairment Alzheimer DiseaseSettore MED/26 - Neurologia
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The Effect of Adherence to the Mediterranean Diet on Late-Life Cognitive Disorders: A Systematic Review

2020

Objectives: Although some results are conflicting, numerous investigations have demonstrated that the Mediterranean Diet (MedDiet) has positive effects on brain health. This review intends to provide an update on the scientific evidence regarding the effects of adherence to the MedDiet on late-life cognitive disorders. Design: A systematic review was performed. The PubMed and Scopus databases were searched for longitudinal studies and randomized controlled trials (RCTs) published between the databases’ inceptions and May 4, 2020. PRISMA guidelines were followed; the quality of the studies was assessed using version 2 of the Cochrane risk-of-bias tool for the RCTs and the Newcastle-Ottawa Sc…

GerontologyMediterranean dietDiseaseMediterraneanDiet Mediterraneanlaw.invention03 medical and health sciences0302 clinical medicineCognitionRandomized controlled trialsystematic reviewlawAlzheimer DiseaseMediterranean dietmedicineDementiaHumansCognitive Dysfunction030212 general & internal medicineEffects of sleep deprivation on cognitive performanceCognitive declineGeneral NursingAgedModalitiesbusiness.industryHealth PolicyCognitionGeneral MedicineAlzheimer's diseaseMiddle Agedmedicine.diseaseMCIDietcognitive decline and performanceAlzheimer's disease; MCI; Mediterranean diet; cognitive decline and performance; dementia; systematic review; Aged; Cognition; Humans; Middle Aged; Alzheimer Disease; Cognition Disorders; Cognitive Dysfunction; Diet MediterraneanGeriatrics and Gerontologysystematic review.businessCognition Disorders030217 neurology & neurosurgerydementia
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Lymphocytic Mitochondrial Aconitase Activity is Reduced in Alzheimer's Disease and Mild Cognitive Impairment

2015

Background: Specific mechanisms behind the role of oxidative/nitrosative stress and mitochondrial dysfunction in Alzheimer's disease (AD) pathogenesis remain elusive. Mitochondrial aconitase (ACO2) is a Krebs cycle enzyme sensitive to free radicalmediated damage. Objective: We assessed activity and expression of ACO2 extracted from blood lymphocytes of subjects with AD, mild cognitive impairment (MCI), older adults with normal cognition (OCN, age >= 65 years), and younger adults with normal cognition (YCN, age < 65 years). Plasma levels and activities of antioxidants were also measured. Methods: Blood samples were collected from 28 subjects with AD, 22 with MCI, 21 OCN, and 19 YCN. ACO2 act…

MalePathologyantioxidantAntioxidantmedicine.medical_treatmentLymphocyteMitochondrionmedicine.disease_causePolymerase Chain ReactionPathogenesisVitamin Eoxidative stressLymphocytesaconitase (aconitate hydratase)Aconitate Hydratasereactive oxygen speciesGeneral NeuroscienceACO2General MedicineAlzheimer's diseasemitochondriaPsychiatry and Mental healthClinical Psychologyantioxidantsmedicine.anatomical_structureDisease ProgressionSettore MED/26 - NeurologiaFemaleAlzheimer diseaseAlzheimer's diseaseAzheimer diseasereactive nitrogen speciemedicine.medical_specialtyaconitase (aconitate hydratase); Alzheimer disease; antioxidants; free radicals; lymphocyte; mild cognitive impairment; mitochondria; oxidative stress; reactive nitrogen species; reactive oxygen speciesBlotting Westernfree radicalslymphocytemild cognitive impairmentInternal medicinemedicineHumansCognitive DysfunctionRNA MessengerAgedfree radicaloxidative strebusiness.industryVitamin EAconitasimedicine.diseasereactive nitrogen speciesEndocrinologyGeriatrics and GerontologyAlzheimer's disease; Aconitasi; oxidative stress; Aconitase (aconitate hydratase) Azheimer disease antioxidants free radicals lymphocyte mild cognitive impairment mitochondria oxidative stress reactive nitrogen species reactive oxygen speciesMental Status SchedulebusinessBiomarkersOxidative stressJournal of Alzheimer's Disease
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Role of physical activity in ameliorating neuropsychiatric symptoms in Alzheimer disease: A narrative review

2019

Objective: Neuropsychiatric symptoms (NPs) affect almost all patients with Alzheimer disease (AD). Because of the complications associated with the pharmacological treatment, nonpharmacological treatment (such as physical activity) can be considered as an additional complementary treatment option for NPs. The aim of this review is to evaluate the impact of physical activity on NPs in patients with AD. Methods: We searched Pubmed and Google Scholar for potential eligible articles until March 1, 2018. Results: Although there are contradictory results showing the impact of physical exercise on NPs, most of them reported that it had a significant effect on depression and sleep disturbances in p…

Hypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPhysical exerciseDiseaseBioinformatics03 medical and health sciences0302 clinical medicineNeurotrophic factorsAlzheimer DiseasemedicineHumansApathyExerciseDepression (differential diagnoses)030214 geriatricsbusiness.industryMental DisordersAlzheimer disease neuropsychiatric symptoms physical activity physical exercisemedicine.diseaseExercise TherapyPsychiatry and Mental healthDisinhibitionA narrative review- INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY cilt.34 sa.9 ss.1316-1325 2019 [Veronese N. Solmi M. Basso C. Smith L. SOYSAL P. -Role of physical activity in ameliorating neuropsychiatric symptoms in Alzheimer disease]AnxietyGeriatrics and Gerontologymedicine.symptomAlzheimer's diseasebusiness
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A second family with familial AD and the V717L APP mutation has a later age at onset

2006

Four mutations have been reported at the 717 codon of the amyloid precursor protein (APP), with valine substituted by isoleucine, glycine, phenylalanine, and leucine. While several families with the isoleucine substitution have been described, the other substitutions have been reported in only one family each worldwide. A family with the V717L APP mutation has been previously reported,1 with a mean age at onset of 38 years (range 35 to 39), based on four affected family members, and a mean age at death of 46 years (range 40 to 50). We have identified a second family with a later mean age at onset of 50 years (range 48 to 57) and mean age at death of 61 years (range 57 to 68). Family 171 is …

MalePediatricsmedicine.medical_specialtyMutation Missensemedicine.disease_causeAmyloid beta-Protein PrecursorAlzheimer DiseaseValineInternal medicinemedicineAmyloid precursor proteinHumansAge of OnsetAgedAge of Onset Aged Alzheimer Disease/genetics Alzheimer Disease/physiopathology Amino Acid Substitution Amyloid beta-Protein Precursor/genetics Female Humans Malle Middle Aged Mutation Missense PedigreeMutationSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicabiologyMean ageMiddle AgedPedigreeEndocrinologyAmino Acid Substitutionbiology.proteinFemaleNeurology (clinical)IsoleucineNeurology
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Thioflavin T templates amyloid β(1–40) conformation and aggregation pathway

2015

Aβ(1-40) peptide supramolecular assembly and fibril formation processes are widely recognized to have direct implications in the progression of Alzheimer's disease. The molecular basis of this biological process is still unknown and there is a strong need of developing effective strategies to control the occurring events. To this purpose the exploitation of small molecules interacting with Aβ aggregation represents one of the possible routes. Moreover, the use specific labeling has represented so far one of the most common and effective methods to investigate such a process. This possibility in turn rests on the reliability of the probe/labels involved. Here we present evidences of the effe…

Protein StructureSecondaryAβ(1–40) peptideAmyloidProtein ConformationMolecular Sequence DataBiophysicsSupramolecular chemistryMolecular Dynamics SimulationProtein aggregationProtein Aggregation PathologicalBiochemistryProtein Structure SecondarySupramolecular assemblyProtein Aggregateschemistry.chemical_compoundProtein structureAlzheimer DiseasePathologicalSecondary structureAβ(1-40) peptideHumansBenzothiazolesAmino Acid SequenceFluorescent DyesAmyloid beta-PeptidesProtein StabilityOrganic ChemistryAlzheimer's diseaseProtein AggregationSmall moleculePeptide FragmentsSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)Peptide ConformationAlzheimer's disease; Aβ(1–40) peptide; Protein aggregation; Protein conformation; Secondary structure; Thioflavin T; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Fluorescence Recovery After Photobleaching; Fluorescent Dyes; Humans; Molecular Dynamics Simulation; Molecular Sequence Data; Peptide Fragments; Protein Aggregates; Protein Aggregation Pathological; Protein Conformation; Protein Multimerization; Protein Stability; Protein Structure Secondary; ThiazolesThiazolesBiophysicBiochemistrychemistryThioflavin TBiophysicsThioflavinProtein MultimerizationFluorescence Recovery After PhotobleachingBiophysical Chemistry
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(±)- BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channe…

2021

Multitarget-directed ligands (MTDLs) are considered a promising therapeutic strategy to address the multifactorial nature of Alzheimer's disease (AD). Novel MTDLs have been designed as inhibitors of human acetylcholinesterases/butyrylcholinesterases, monoamine oxidase A/B, and glycogen synthase kinase 3β and as calcium channel antagonists via the Biginelli multicomponent reaction. Among these MTDLs, (±)-BIGI-3h was identified as a promising new hit compound showing in vitro balanced activities toward the aforementioned recognized AD targets. Additional in vitro studies demonstrated antioxidant effects and brain penetration, along with the ability to inhibit the aggregation of both τ protein…

cholinesterasePhysiologyMonoamine oxidaseCognitive NeuroscienceLigandPharmacologyLigandsCalcium ChannelBiochemistry03 medical and health sciences0302 clinical medicineAlzheimer DiseaseIn vivoGSK-3HumansCholinesterasesCholinesterase InhibitorBiginelli reactionAlzheimer's disease; Biginelli reaction; calcium channel; cholinesterases; GSK 3β; MAO; Calcium Channel Blockers; Calcium Channels; Cholinesterase Inhibitors; Glycogen Synthase Kinase 3 beta; Humans; Ligands; Monoamine Oxidase; Alzheimer DiseaseMonoamine OxidaseGSK3B030304 developmental biologyCholinesterase0303 health sciencesGlycogen Synthase Kinase 3 betaVoltage-dependent calcium channelbiologyChemistryCalcium channelCell BiologyGeneral MedicineAlzheimer's diseaseCalcium Channel BlockersCalcium channel GSK 3β MAOMAObiology.proteinCalcium ChannelsCholinesterase InhibitorsGSK 3βMonoamine oxidase ACalcium Channel BlockerAlzheimer’s disease030217 neurology & neurosurgeryHuman
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